"Hamartia" - noun [$10]
Hamartia means the fatal flaw leading to the destruction of the tragic hero or heroine.
Sentence: What is the hamartia of Hamlet? I argue a general greed created a lack of focus permitting multiple conflicting objectives: revenge against his father's murderer, desire to bring his mother down, and desire for the throne. The lack of focus caused him to dither and delay, make blunders, and miss opportunities. Unable to focus on a single objective, he completely bollixed up the entire effort.